Since the effects will be switched on/off via Midi according to the effects position (a,b,c,d,x ...) and not by the used type (like in the AxeFx) - we'll need some consideration.
Effect setups I use are like this:
(General use)
wah - compressor - overdrive - distortion - (Amp/EQ/Cab) - StereoWidener - Chorus - Delay - Reverb
(For external effects)
wah - compressor - overdrive - loop - (Amp/EQ/Cab) - StereoWidener - Chorus - Delay - Reverb
(For max sound tweaking via the EQ blocks)
wah - compressor - drive - EQ - (Amp/EQ/Cab) - EQ - Chorus - Delay - Reverb